Substances (GSRS)

HPN3

Also: NAV 1.8, NAV1.8, PERIPHERAL NERVE SODIUM CHANNEL 3 +4

proteinUNII E3COJ2T10W
Open FDA's page for this record
Substance class
protein
Definition type
PRIMARY
Definition level
COMPLETE
Uuid
46a4aece-8f01-4331-a7eb-57f1d45ccdef
Version
23
UNII
E3COJ2T10W
Codes
  1. Uuid
    f0864e58-d296-4a12-9729-12f4c4eb4664
    Code
    Q9Y5Y9
    Type
    PRIMARY
    Url
    http://www.uniprot.org/uniprot/Q9Y5Y9?sort=score
    Code system
    UNIPROT
    References
    65f24420-e465-44fc-b6f3-0d7e1471d29f
  2. Uuid
    869e5685-deff-423f-a50d-7cbe957e8389
    Code
    Q9Y5Y9
    Type
    PRIMARY
    Url
    https://pharos.nih.gov/idg/search?q=Q9Y5Y9
    Code system
    PHAROS
    References
    65f24420-e465-44fc-b6f3-0d7e1471d29f
  3. Uuid
    f92a9930-40d5-43ee-a7a7-460a5ee632dc
    Code
    E3COJ2T10W
    Type
    PRIMARY
    Code system
    FDA UNII
References
  1. Uuid
    78f054d7-416b-4f08-baf3-eabc4a560412
    Citation
    http://www.uniprot.org/uniprot/Q9Y5Y9
    Url
    http://www.uniprot.org/uniprot/Q9Y5Y9
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN, PUBLIC_DOMAIN_RELEASE, AUTO_SELECTED
  2. Uuid
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e
    Citation
    UNIPROT
    Doc type
    UNIPROT
    Public domain
    true
    Tags
    NOMEN
  3. Uuid
    0701f068-cf90-4728-827a-c70b0ecd1534
    Citation
    http://www.uniprot.org/uniprot/Q9Y5Y9?sort=score
    Url
    http://www.uniprot.org/uniprot/Q9Y5Y9?sort=score
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN
  4. Uuid
    1c80b8af-56b7-4f42-9780-ece973299c3e
    Citation
    fda_srs
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN
  5. Uuid
    65f24420-e465-44fc-b6f3-0d7e1471d29f
    Citation
    SRS CODE IMPORT
    Doc type
    SRS
    Public domain
    true
    Document date
    1493393828000
    Tags
    NOMEN
  6. Uuid
    9a884a56-9b7c-4e34-8ee9-a7a1ca025cd8
    Citation
    https://en.wikipedia.org/wiki/PF-05089771
    Url
    https://en.wikipedia.org/wiki/PF-05089771
    Doc type
    WEBSITE
    Public domain
    true
    Tags
    NOMEN
  7. Uuid
    c8ef6f36-5ad0-47aa-a864-c72fdac89600
    Citation
    SRS import [E3COJ2T10W]
    Url
    http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=E3COJ2T10W
    Doc type
    SRS
    Public domain
    true
    Document date
    1493393828000
    Tags
    NOMEN
  8. Uuid
    507c1fbd-eeba-4919-8116-3e5e55355676
    Citation
    https://www.sciencedirect.com/science/article/pii/S0014299918300530
    Url
    https://www.sciencedirect.com/science/article/pii/S0014299918300530
    Doc type
    JA
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  9. Uuid
    6e533a79-e3e9-49f7-b1e1-7a80204974e1
    Citation
    USAN COUN 2023
    Doc type
    USANCOUN
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  10. Uuid
    bd27bbd5-4f6b-4bfa-bc7c-f703adade45e
    Citation
    WO2021257490 (Scifinder ref)
    Doc type
    PATENT
    Public domain
    true
  11. Uuid
    c16d7e43-b7ba-4ca7-8833-5574b2a6b181
    Citation
    USAN COUN 2023
    Doc type
    USANCOUN
    Public domain
    true
Relationships
  1. Uuid
    54f609d0-4d40-4e5c-81ec-f11e923573f0
    Type
    INHIBITOR->TARGET
    Amount
    Uuid
    64dc28dc-c727-419a-b6e9-fcfc41f0e42a
    Related substance
    Uuid
    112a267f-99af-460a-a76b-07620ae99857
    Refuuid
    de5be196-a77f-462c-b39b-64fd1e3f76ad
    Name
    BLIRETRIGINE
    UNII
    9B6BM88NXN
    Linking ID
    9B6BM88NXN
    Ref pname
    BLIRETRIGINE
  2. Uuid
    e886cfb0-8fc0-43cb-bc38-82585644609c
    Type
    INHIBITOR->TARGET
    Amount
    Uuid
    5f2d6312-5009-4d3f-a312-e50083cd563a
    References
    6e533a79-e3e9-49f7-b1e1-7a80204974e1
    Related substance
    Uuid
    f0ca8741-84ee-40fb-80ba-6fe3645d03ec
    Refuuid
    aee33bca-8219-4c16-89ed-c73f65afe9a9
    Name
    Suzetrigine
    UNII
    LOG73M21H5
    Linking ID
    LOG73M21H5
    Ref pname
    Suzetrigine
  3. Uuid
    6aa93ad9-c71b-49da-80ea-4df3fd9a7c70
    Type
    INHIBITOR->TARGET
    Amount
    Uuid
    e96a51ce-1a0e-45f7-86f8-26ff0890bad7
    References
    507c1fbd-eeba-4919-8116-3e5e55355676
    Related substance
    Uuid
    af50fc43-640d-431e-a3b0-6faf85657857
    Refuuid
    3aa64343-1e50-4ea2-bd9d-3dfb117160ef
    Name
    PRIRALFINAMIDE
    UNII
    3LPF0S0GVV
    Linking ID
    3LPF0S0GVV
    Ref pname
    PRIRALFINAMIDE
    Substance class
    reference
Names
  1. Uuid
    f17f2af7-9bc1-4628-b9b2-31cd4a040180
    Name
    HPN3
    StdName
    HPN3
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e, 0701f068-cf90-4728-827a-c70b0ecd1534
  2. Uuid
    3e2d7334-ddd2-494b-8d63-e4bee81ff97d
    Name
    NAV 1.8
    StdName
    NAV 1.8
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    1c80b8af-56b7-4f42-9780-ece973299c3e, f6c28cf1-2545-4a63-a48c-8fadb00f3e6e
  3. Uuid
    b1380955-34eb-4b66-ab6e-a16c9dc956f7
    Name
    NAV1.8
    StdName
    NAV1.8
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    1c80b8af-56b7-4f42-9780-ece973299c3e, f6c28cf1-2545-4a63-a48c-8fadb00f3e6e
  4. Uuid
    a8606e54-e189-41d4-a045-36df9f2cc07e
    Name
    PERIPHERAL NERVE SODIUM CHANNEL 3
    StdName
    PERIPHERAL NERVE SODIUM CHANNEL 3
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e, 0701f068-cf90-4728-827a-c70b0ecd1534
  5. Uuid
    374fb1d2-5d61-4237-97e2-43d86a12def3
    Name
    PN3
    StdName
    PN3
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e, 0701f068-cf90-4728-827a-c70b0ecd1534
  6. Uuid
    a57c6d96-f725-4bd2-b4fa-b5faeba67767
    Name
    SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA
    StdName
    SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA
    Type
    cn
    Preferred
    false
    Display name
    true
    Languages
    en
    References
    78f054d7-416b-4f08-baf3-eabc4a560412, f6c28cf1-2545-4a63-a48c-8fadb00f3e6e
  7. Uuid
    cded4a32-ebc1-470c-bd7e-ff62d97dfb2c
    Name
    SODIUM CHANNEL PROTEIN TYPE X SUBUNIT ALPHA
    StdName
    SODIUM CHANNEL PROTEIN TYPE X SUBUNIT ALPHA
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e, 0701f068-cf90-4728-827a-c70b0ecd1534
  8. Uuid
    cb50696d-9932-47f5-ac6f-7f152cb7b241
    Name
    VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.8
    StdName
    VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.8
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    f6c28cf1-2545-4a63-a48c-8fadb00f3e6e, 0701f068-cf90-4728-827a-c70b0ecd1534
Protein
Uuid
1fef81b2-abd1-4441-a0cf-4c5a2f17d05c
Sequence type
COMPLETE
Glycosylation
Uuid
faecb38a-8b05-43e6-956b-9ab4e588ceef
Glycosylation type
HUMAN
N glycosylation sites
  1. Residue index
    284
    Subunit index
    1
  2. Residue index
    288
    Subunit index
    1
  3. Residue index
    312
    Subunit index
    1
  4. Residue index
    335
    Subunit index
    1
  5. Residue index
    819
    Subunit index
    1
  6. Residue index
    1312
    Subunit index
    1
  7. Residue index
    1328
    Subunit index
    1
  8. Residue index
    1336
    Subunit index
    1
  9. Residue index
    1686
    Subunit index
    1
Subunits
  1. Uuid
    81f4f14b-742f-4cd4-94cc-857e99054ff1
    Subunit index
    1
    Sequence

    MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP

References
78f054d7-416b-4f08-baf3-eabc4a560412, c8ef6f36-5ad0-47aa-a864-c72fdac89600
Properties
  1. Uuid
    485fc6ed-31f1-48a7-8634-195791502f30
    Name
    MOL_WEIGHT
    Type
    amount
    Defining
    false
    Property type
    CHEMICAL
    Value
    Uuid
    651e27c8-0ce2-4185-bccb-26fd399e06e2
    Units
    DA
Modifications
Uuid
4fa495d6-21a6-4bec-a89c-18525d108dca
Structural modifications
  1. Uuid
    d4d5a504-0c78-4571-9f8d-9f1802bd9e03
    Extent
    COMPLETE
    Structural modification type
    AMINO ACID SUBSTITUTION
    Sites
    1. Residue index
      1451
      Subunit index
      1
    Molecular fragment
    Uuid
    319c453a-940a-41e4-b506-84bf62c6fa77
    Refuuid
    b6eb2edb-1b4d-46ad-92ad-a43f0f545926
    Name
    DEXFOSFOSERINE
    UNII
    VI4F0K069V
    Linking ID
    VI4F0K069V
    Ref pname
    DEXFOSFOSERINE
    Substance class
    reference
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Data from openFDA, FDA's public API. FDA says not to rely on it to make decisions about medical care and to treat every result as unvalidated; confirm against FDA's own record and the product labeling. Not medical or legal advice.