Substances (GSRS)

Firsekibart

Also: H-gamma4 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-49*05 (94.0%) -(IGHD) -IGHJ6*01 (94.4%), CDRIMGT [8.10.19] (26-33.51-60.9…

proteinUNII 6ZU8B6H4KT
Open FDA's page for this record
Substance class
protein
Definition type
PRIMARY
Definition level
COMPLETE
Uuid
64bdef5b-1b6f-41be-96c2-7dd9554fb1d1
Version
6
UNII
6ZU8B6H4KT
Codes
  1. Uuid
    63f1093f-c670-4325-b112-798a820d3346
    Code
    13353
    Type
    PRIMARY
    Url
    https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=13353
    Code system
    INN
    References
    b0e8c07c-1e6d-44d6-8e0f-5cea8fa1b8a0
  2. Uuid
    4b1dadaa-7cde-4dc8-85cc-96291071a831
    Code
    2981430-39-9
    Type
    PRIMARY
    Url
    https://commonchemistry.cas.org/detail?cas_rn=2981430-39-9
    Code system
    CAS
    References
    6e46a02b-0d50-4eba-a025-91f3d8568264
  3. Uuid
    8a87930a-d876-407e-b94b-5befe0bac373
    Code
    6ZU8B6H4KT
    Type
    PRIMARY
    Code system
    FDA UNII
Relationships
  1. Uuid
    b50501a8-0de2-4635-94e3-a5c43e92057b
    Type
    TARGET->INHIBITOR
    Amount
    Uuid
    8f1877d8-d6b0-455d-800f-7a291a477f0d
    Related substance
    Uuid
    5f8be815-19ec-4960-be3e-ec92096c4564
    Refuuid
    ef6392d7-bd67-4859-b5f4-8cc6ee6ad73f
    Name
    INTERLEUKIN-1 .BETA. HUMAN
    UNII
    X62226112J
    Linking ID
    X62226112J
    Ref pname
    INTERLEUKIN-1 .BETA. HUMAN
    Substance class
    reference
  2. Uuid
    dd7cc6d4-1316-4136-a41f-73513e146f77
    Type
    ACTIVE MOIETY
    Amount
    Uuid
    b086990f-a6e5-424c-959d-e46ee26e08ae
    References
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
    Related substance
    Uuid
    f42719a5-2ea0-4a67-8bd1-a537749e7470
    Refuuid
    64bdef5b-1b6f-41be-96c2-7dd9554fb1d1
    Name
    Firsekibart
    UNII
    6ZU8B6H4KT
    Linking ID
    6ZU8B6H4KT
    Ref pname
    Firsekibart
    Substance class
    reference
Names
  1. Uuid
    0d284be9-e175-4b9e-9309-3213df2d8302
    Name
    Firsekibart
    StdName
    FIRSEKIBART
    Type
    of
    Preferred
    false
    Display name
    true
    Languages
    en
    References
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
    Domains
    Protein Drug
    Name orgs
    1. Uuid
      7e128e7c-19dd-4310-8ca2-e26a8d69b604
      Name org
      INN
  2. Uuid
    4bcad751-5725-4455-918c-c622e5bcc6a6
    Type
    cn
    Preferred
    false
    Display name
    false
    Name

    H-gamma4 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-49*05 (94.0%) -(IGHD) -IGHJ6*01 (94.4%), CDRIMGT [8.10.19] (26-33.51-60.99-117)) (1-128) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, 12-G4v5 h P10(CH1 (129-226), hinge 1-12 S10>P (236) (227-238), CH2 L92 (317) (239-348), CH3 (349-453), CHS (454-455)) (129-455)], (142-211')-disulfide with L-lambda2 light chain Homo sapiens (1'-212') [V-LAMBDA (Homo sapiens IGLV3-1*01 (96.8%) -IGLJ2*01 (100%), CDR-IMGT [6.3.9] (26'-31'.49'-51'.88'-96')) (1'-106') -Homo sapiens IGLC2*01 (100%) (C-LAMBDA2) (107'-212')]; dimer (234-234'':237-237'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

    StdName

    H-GAMMA4 HEAVY CHAIN HOMO SAPIENS (1-455) (VH (HOMO SAPIENS IGHV3-49*05 (94.0%) -(IGHD) -IGHJ6*01 (94.4%), CDRIMGT (8.10.19) (26-33.51-60.99-117)) (1-128) -HOMO SAPIENS IGHG4*01, NG4M(A) CH2 L92, 12-G4V5 H P10(CH1 (129-226), HINGE 1-12 S10>P (236) (227-238), CH2 L92 (317) (239-348), CH3 (349-453), CHS (454-455)) (129-455)), (142-211')-DISULFIDE WITH L-LAMBDA2 LIGHT CHAIN HOMO SAPIENS (1'-212') (V-LAMBDA (HOMO SAPIENS IGLV3-1*01 (96.8%) -IGLJ2*01 (100%), CDR-IMGT (6.3.9) (26'-31'.49'-51'.88'-96')) (1'-106') -HOMO SAPIENS IGLC2*01 (100%) (C-LAMBDA2) (107'-212')); DIMER (234-234'':237-237'')-BISDISULFIDE, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, CELL LINE CHO-K1, GLYCOFORM ALFA

    Languages
    en
    References
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
  3. Uuid
    3de3d390-b5a6-4634-bb4b-f89b8214ac30
    Name
    Immunoglobulin G4 [236-proline], anti-(human interleukin 1β) (human monoclonal GenSci048 γ4-chain), disulfide with human monoclonal GenSci048 λ-chain, dimer
    Type
    cn
    Preferred
    false
    Display name
    false
    StdName

    IMMUNOGLOBULIN G4 (236-PROLINE), ANTI-(HUMAN INTERLEUKIN 1.BETA.) (HUMAN MONOCLONAL GENSCI048 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL GENSCI048 .LAMBDA.-CHAIN, DIMER

    Languages
    en
    References
    6e46a02b-0d50-4eba-a025-91f3d8568264
  4. Uuid
    a7b8722b-73ec-400f-8adb-140c8f9bcd9e
    Name
    firsekibart [INN]
    StdName
    FIRSEKIBART [INN]
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
  5. Uuid
    570cbaea-868f-44c7-9fa9-068f777f3544
    Name
    immunoglobulin G4-lambda2, anti-[Homo sapiens IL1B (interleukin 1 beta, IL-1B, 1L1F2)], Homo sapiens monoclonal antibody
    StdName
    IMMUNOGLOBULIN G4-LAMBDA2, ANTI-(HOMO SAPIENS IL1B (INTERLEUKIN 1 BETA, IL-1B, 1L1F2)), HOMO SAPIENS MONOCLONAL ANTIBODY
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
References
  1. Uuid
    b0e8c07c-1e6d-44d6-8e0f-5cea8fa1b8a0
    Citation
    Mednet
    Doc type
    INN
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  2. Uuid
    6e46a02b-0d50-4eba-a025-91f3d8568264
    Citation
    STN
    Doc type
    STN (SCIFINDER)
    Public domain
    true
  3. Uuid
    8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
    Citation
    List 132
    Url
    https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl132.pdf
    Doc type
    INN
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
Protein
Uuid
21ff06a0-cd6d-4bfa-9ce4-c21b19f30b51
Protein sub type
IGG4
Protein type
MONOCLONAL ANTIBODY
Sequence origin
HUMAN
Sequence type
COMPLETE
Glycosylation
Uuid
c00b4769-80d8-4c7e-82a3-5c9d70b2177e
Glycosylation type
MAMMALIAN
N glycosylation sites
  1. Residue index
    305
    Subunit index
    1
  2. Residue index
    305
    Subunit index
    2
Subunits
  1. Uuid
    b2592be6-e8bf-424c-95bc-97e4500f40aa
    Subunit index
    1
    Sequence

    EVQLVESGGGLVKPGRSLRLSCTGSGFTFGDYALNWFRQAPGMGLEWVGFIRGKAYGGTTEYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCNREVEYCRSSENYCYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK

  2. Uuid
    171def84-0f2a-4dd2-8e18-acab02503826
    Subunit index
    2
    Sequence

    EVQLVESGGGLVKPGRSLRLSCTGSGFTFGDYALNWFRQAPGMGLEWVGFIRGKAYGGTTEYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCNREVEYCRSSENYCYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK

  3. Uuid
    4ad4e660-d193-40fd-81a5-06721ff70b5c
    Subunit index
    3
    Sequence

    SYELTQPPSVSVSPGQTASITCSGDKLGDKFACWYQQKPGQSPVLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSNTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

  4. Uuid
    028e1e87-9e66-4230-b91d-77d49f950d6e
    Subunit index
    4
    Sequence

    SYELTQPPSVSVSPGQTASITCSGDKLGDKFACWYQQKPGQSPVLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSNTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

References
8cd8fe44-b46f-4baf-9d13-cc08c114cbc9
Disulfide links
  1. Sites
    1. Residue index
      134
      Subunit index
      4
    2. Residue index
      193
      Subunit index
      4
  2. Sites
    1. Residue index
      22
      Subunit index
      4
    2. Residue index
      87
      Subunit index
      4
  3. Sites
    1. Residue index
      134
      Subunit index
      3
    2. Residue index
      193
      Subunit index
      3
  4. Sites
    1. Residue index
      22
      Subunit index
      3
    2. Residue index
      87
      Subunit index
      3
  5. Sites
    1. Residue index
      375
      Subunit index
      2
    2. Residue index
      433
      Subunit index
      2
  6. Sites
    1. Residue index
      269
      Subunit index
      2
    2. Residue index
      329
      Subunit index
      2
  7. Sites
    1. Residue index
      155
      Subunit index
      2
    2. Residue index
      211
      Subunit index
      2
  8. Sites
    1. Residue index
      142
      Subunit index
      2
    2. Residue index
      211
      Subunit index
      4
  9. Sites
    1. Residue index
      105
      Subunit index
      2
    2. Residue index
      112
      Subunit index
      2
  10. Sites
    1. Residue index
      22
      Subunit index
      2
    2. Residue index
      98
      Subunit index
      2
  11. Sites
    1. Residue index
      375
      Subunit index
      1
    2. Residue index
      433
      Subunit index
      1
  12. Sites
    1. Residue index
      269
      Subunit index
      1
    2. Residue index
      329
      Subunit index
      1
  13. +6 more not shown
Modifications
Uuid
f5e4bd68-0e5b-43da-93b3-0a66b2dcebb7
Structural modifications
  1. Uuid
    4951cbb5-ad49-49fa-b26b-611db5a4d46a
    Extent
    COMPLETE
    Location type
    C-TERMINUS
    Residue modified
    K
    Structural modification type
    AMINO ACID REMOVAL
    Sites
    1. Residue index
      455
      Subunit index
      1
    2. Residue index
      455
      Subunit index
      2
    Molecular fragment
    Uuid
    23d919ec-da45-4f8b-bbc2-dc010861172d
    Refuuid
    e86b6ffd-b009-4d29-a2fd-c10b944f4ece
    Name
    LYSINE
    UNII
    K3Z4F929H6
    Linking ID
    K3Z4F929H6
    Ref pname
    LYSINE
    Substance class
    reference
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Data from openFDA, FDA's public API. FDA says not to rely on it to make decisions about medical care and to treat every result as unvalidated; confirm against FDA's own record and the product labeling. Not medical or legal advice.