Substances (GSRS)

9ac41ec0-5260-4644-8707-4644436290cd

protein
Substance class
protein
Definition type
ALTERNATIVE
Definition level
COMPLETE
Uuid
9ac41ec0-5260-4644-8707-4644436290cd
Version
2
Relationships
  1. Uuid
    14bae2a8-0bd5-41f0-801c-401f5021386a
    Type
    SUB_ALTERNATE->SUBSTANCE
    Amount
    Uuid
    d1263461-1e8d-4a20-bf23-a2253fe572bb
    Related substance
    Uuid
    0699dd61-b5e6-4b19-86fe-62949d10ca7b
    Refuuid
    ffb20e37-50c5-49df-9d9d-611a13869513
    Name
    APAMISTAMAB
    UNII
    55NP7G3PGH
    Linking ID
    55NP7G3PGH
    Ref pname
    APAMISTAMAB
    Substance class
    reference
References
  1. Uuid
    35e8886f-585f-86f5-025e-438daded5070
    Url
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193629/
    Doc type
    JA
    Public domain
    true
    Citation

    Li Y, Hamlin DK, Chyan MK, Wong R, Dorman EF, Emery RC, Woodle DR, Manger RL, Nartea M, Kenoyer AL, Orozco JJ, Green DJ, Press OW, Storb R, Sandmaier BM, Wilbur DS. cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies. PLoS One. 2018 Oct 18;13(10):e0205135. doi: 10.1371/journal.pone.0205135. PMID: 30335787; PMCID: PMC6193629.

    Tags
    PUBLIC_DOMAIN_RELEASE
  2. Uuid
    d1ab1961-0473-71c1-34c5-390075658eb2
    Citation
    FDA_SRS
    Doc type
    INN
    Public domain
    true
  3. Uuid
    a85e5ae5-819e-2206-951c-41f6325a2b7a
    Citation
    INN LIST 110
    Doc type
    INN_LIST
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  4. Uuid
    59da9894-4225-cf1d-7f4a-ab62af659042
    Doc type
    SYSTEM
    Public domain
    true
  5. Uuid
    7e8c21ad-943d-a7b1-edc3-f6f04ed1b0c6
    Citation
    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1961
    Doc type
    NCI THESAURUS
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  6. Uuid
    a4c6333a-311c-fcec-d50d-e5d0309cecff
    Citation
    SRS import [[ingredient] 0254911AA]
    Url
    http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=[ingredient] 0254911AA
    Doc type
    SRS
    Public domain
    true
    Document date
    1493394609000
    Tags
    NOMEN
  7. Uuid
    6920edf5-57f5-0985-acb8-6c18c5714463
    Citation
    NCIT
    Doc type
    NCI THESAURUS
    Public domain
    true
  8. Uuid
    42d54601-50e2-2a0e-cb8e-c38eb5308691
    Url
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193629/
    Doc type
    JA
    Public domain
    true
    Citation

    A Li Y, Hamlin DK, Chyan MK, et al. cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies. PLoS One. 2018;13(10):e0205135. Published 2018 Oct 18. doi:10.1371/journal.pone.0205135

Protein
Uuid
aef6095f-5bbb-556c-be0e-63a064b06424
Protein sub type
IGG1
Protein type
MONOCLONAL ANTIBODY
Sequence origin
MOUSE
Sequence type
COMPLETE
Glycosylation
Uuid
2dee2a03-b644-d457-8f1c-bf53a630bfec
Glycosylation type
MAMMALIAN
N glycosylation sites
  1. Residue index
    59
    Subunit index
    1
  2. Residue index
    295
    Subunit index
    1
  3. Residue index
    59
    Subunit index
    2
  4. Residue index
    295
    Subunit index
    2
Subunits
  1. Uuid
    d582adfb-194e-a958-16e6-130b02f88b71
    Subunit index
    1
    Sequence

    EVKLLESGGGLVQPGGSLKLSCAASGFDFSRYWMSWVRQAPGKGLEWLGEINTPSSTLNFTPSLKDKVFISRDNAKNTLYLQMSKVRSEDTALYYCARGNYYRYGDAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTDSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK

  2. Uuid
    286ddc4a-0422-3501-3c20-ca2c59baf186
    Subunit index
    2
    Sequence

    EVKLLESGGGLVQPGGSLKLSCAASGFDFSRYWMSWVRQAPGKGLEWLGEINTPSSTLNFTPSLKDKVFISRDNAKNTLYLQMSKVRSEDTALYYCARGNYYRYGDAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTDSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK

  3. Uuid
    a5f21a3b-3369-1cd2-dca8-3a160af4edee
    Subunit index
    3
    Sequence

    DIALQTSPASLAVSLGQRATISCRASKSVSTSGYSYLHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

  4. Uuid
    bdf70adc-2704-f766-0666-071f74e94a89
    Subunit index
    4
    Sequence

    DIALQTSPASLAVSLGQRATISCRASKSVSTSGYSYLHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

References
7e8c21ad-943d-a7b1-edc3-f6f04ed1b0c6
Disulfide links
  1. Sites
    1. Residue index
      22
      Subunit index
      2
    2. Residue index
      96
      Subunit index
      2
  2. Sites
    1. Residue index
      22
      Subunit index
      1
    2. Residue index
      96
      Subunit index
      1
  3. Sites
    1. Residue index
      148
      Subunit index
      1
    2. Residue index
      203
      Subunit index
      1
  4. Sites
    1. Residue index
      259
      Subunit index
      2
    2. Residue index
      319
      Subunit index
      2
  5. Sites
    1. Residue index
      365
      Subunit index
      2
    2. Residue index
      423
      Subunit index
      2
  6. Sites
    1. Residue index
      23
      Subunit index
      3
    2. Residue index
      92
      Subunit index
      3
  7. Sites
    1. Residue index
      23
      Subunit index
      4
    2. Residue index
      92
      Subunit index
      4
  8. Sites
    1. Residue index
      223
      Subunit index
      1
    2. Residue index
      218
      Subunit index
      3
  9. Sites
    1. Residue index
      225
      Subunit index
      1
    2. Residue index
      225
      Subunit index
      2
  10. Sites
    1. Residue index
      228
      Subunit index
      1
    2. Residue index
      228
      Subunit index
      2
  11. Sites
    1. Residue index
      230
      Subunit index
      1
    2. Residue index
      230
      Subunit index
      2
  12. Sites
    1. Residue index
      259
      Subunit index
      1
    2. Residue index
      319
      Subunit index
      1
  13. +5 more not shown
Properties
  1. Uuid
    382dca6d-7d45-36b7-a5de-f13fe7ac1c34
    Name
    MOL_WEIGHT:NUMBER(CALCULATED)
    Type
    amount
    Defining
    false
    Property type
    CHEMICAL
    Value
    Uuid
    cd6a510e-986f-502e-6943-584352670c0b
    Type
    ESTIMATED
    Average
    146000
    Units
    Da
  2. Uuid
    d46775da-951b-fb2a-3393-126e4eb6e76c
    Name
    Molecular Formula
    Defining
    false
    Property type
    CHEMICAL
    Value
    Uuid
    27b23b56-4bf8-e58c-7519-222d80b36a95
    Type
    ESTIMATED
    Non numeric value
    C6492H9998O2022N1716S52
Modifications
Uuid
456b3ea3-b3f7-629e-6f84-86c8bf06ea3a
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Data from openFDA, FDA's public API. FDA says not to rely on it to make decisions about medical care and to treat every result as unvalidated; confirm against FDA's own record and the product labeling. Not medical or legal advice.