Substances (GSRS)

AUTOLOGOUS T CELLS, TRANSDUCED WITH A REPLICATION INCOMPETENT MOLONEY MURINE LEUKEMIA VIRUS (MOMLV)…

Also: TEBROCABTAGENE AUTOLEUCEL, tebrocabtagene autoleucel [INN]

structurallyDiverseUNII W86XKJ6C6Y
Open FDA's page for this record
Substance class
structurallyDiverse
Definition type
PRIMARY
Definition level
COMPLETE
Uuid
ce1b7745-fcc1-4268-8757-b938ceb3ef8d
Version
9
UNII
W86XKJ6C6Y
Codes
  1. Uuid
    4341df9e-84be-4ebe-9b24-d6c7db3e05e0
    Code
    11110
    Type
    PRIMARY
    Url
    https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=11110
    Code system
    INN
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
  2. Uuid
    618411fe-5ba0-48c1-aa9d-0de1e3da5a39
    Code
    W86XKJ6C6Y
    Type
    PRIMARY
    Code system
    FDA UNII
  3. Uuid
    ae602b2b-a7e6-52c0-9b97-87bae48366c8
    Code
    C174931
    Type
    PRIMARY
    Url
    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C174931
    Code system
    NCI_THESAURUS
    References
    264d4b12-77d6-5689-3de7-8fe978e69103
  4. Uuid
    65fd03cd-792f-2bd7-1a2d-ca7cbab43198
    Code
    300000018839
    Type
    PRIMARY
    Code system
    SMS_ID
    References
    53a6c00f-daf1-22cf-b100-aa0cb9f79451
Relationships
  1. Uuid
    0ad18b7d-101a-4b45-afc5-492f7809cfb4
    Type
    ACTIVE MOIETY
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
    Related substance
    Uuid
    9d5e6fe4-2dd4-4df3-b37b-bd457e9691fd
    Refuuid
    ce1b7745-fcc1-4268-8757-b938ceb3ef8d
    Name
    TEBROCABTAGENE AUTOLEUCEL
    UNII
    W86XKJ6C6Y
    Linking ID
    W86XKJ6C6Y
    Ref pname
    TEBROCABTAGENE AUTOLEUCEL
    Substance class
    reference
  2. Uuid
    76eb8995-030f-4d06-932e-c67a40833f2d
    Type
    TARGET->LIGAND
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
    Related substance
    Uuid
    71056121-5161-44f2-9041-183134c4c5aa
    Refuuid
    30a81539-3fd9-4059-953d-e54e956e5eba
    Name
    B-LYMPHOCYTE ANTIGEN CD19
    UNII
    IYZ9TI08W3
    Linking ID
    IYZ9TI08W3
    Ref pname
    B-LYMPHOCYTE ANTIGEN CD19
    Substance class
    reference
Names
  1. Uuid
    0ecafc78-bdce-21e1-7763-ddc33636868c
    Type
    cn
    Preferred
    false
    Display name
    false
    Name

    AUTOLOGOUS T CELLS, TRANSDUCED WITH A REPLICATION INCOMPETENT MOLONEY MURINE LEUKEMIA VIRUS (MOMLV) (A RETROVIRUS) VECTOR THAT ENCODES A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN B-LYMPHOCYTE ANTIGEN CD19 (CD19 MOLECULE, B-LYMPHOCYTE SURFACE ANTIGEN B4, T-CELL SURFACE ANTIGEN LEU-12, CVID3)

    StdName

    AUTOLOGOUS T CELLS, TRANSDUCED WITH A REPLICATION INCOMPETENT MOLONEY MURINE LEUKEMIA VIRUS (MOMLV) (A RETROVIRUS) VECTOR THAT ENCODES A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN B-LYMPHOCYTE ANTIGEN CD19 (CD19 MOLECULE, B-LYMPHOCYTE SURFACE ANTIGEN B4, T-CELL SURFACE ANTIGEN LEU-12, CVID3)

    Languages
    en
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
  2. Uuid
    7cdd9cfb-37ab-e815-0f98-248db9eeca67
    Name
    TEBROCABTAGENE AUTOLEUCEL
    StdName
    TEBROCABTAGENE AUTOLEUCEL
    Type
    of
    Preferred
    false
    Display name
    true
    Languages
    en
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
    Name orgs
    1. Uuid
      8fccac8f-4c12-477d-af5d-8de5309c181b
      Name org
      INN
  3. Uuid
    bdd83b1a-068a-90b5-babd-f732fd5b4d76
    Name
    tebrocabtagene autoleucel [INN]
    StdName
    TEBROCABTAGENE AUTOLEUCEL [INN]
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    dd2f6acb-d457-3594-dd08-7f6c088ce449
References
  1. Uuid
    dd2f6acb-d457-3594-dd08-7f6c088ce449
    Citation
    INN Proposed List 121
    Url
    https://www.who.int/medicines/publications/druginformation/innlists/PL121.pdf
    Doc type
    INN_LIST
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  2. Uuid
    264d4b12-77d6-5689-3de7-8fe978e69103
    Citation
    NCIT
    Doc type
    NCI THESAURUS
    Public domain
    true
  3. Uuid
    53a6c00f-daf1-22cf-b100-aa0cb9f79451
    Citation
    SMS
    Doc type
    EMA LIST
    Public domain
    true
Structurally diverse
Uuid
785ebf9c-7404-48d5-87cd-4b8cce754c6a
Fraction material type
cells
Fraction name
t-cell
Source material class
ORGANISM
Source material state
LIVE GENETICALLY MODIFIED
Source material type
AUTOLOGOUS HUMAN
Parent substance
Uuid
a71776c1-773f-4300-83ad-88f07f95eadb
Refuuid
973bd8f6-2f9b-4f89-8143-9125fe597dc5
Name
HOMO SAPIENS WHOLE
UNII
G0T704E6Z3
Linking ID
G0T704E6Z3
Ref pname
HOMO SAPIENS WHOLE
Substance class
reference
Part
blood
References
dd2f6acb-d457-3594-dd08-7f6c088ce449
Modifications
Uuid
54acf510-8845-4696-8601-c97db3971271
Agent modifications
  1. Uuid
    78e82750-dbf8-4a47-8713-45cac55f32b9
    Agent modification type
    RETROVIRAL TRANSFECTION
    Agent substance
    Uuid
    7b40fcbd-114a-4119-aac8-4c6d5341e570
    Refuuid
    517773e4-c68b-90bc-5197-1933ad879d78
    Name
    MOLONEY MURINE LEUKEMIA VIRUS (MOMLV) (A RETROVIRUS) VECTOR ENCODES A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN B-LYMPHOCYTE ANTIGEN CD19
    UNII
    1T4Q3KIT5R
    Linking ID
    1T4Q3KIT5R
    Ref pname
    MOLONEY MURINE LEUKEMIA VIRUS (MOMLV) (A RETROVIRUS) VECTOR ENCODES A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING HUMAN B-LYMPHOCYTE ANTIGEN CD19
    Substance class
    reference
Structural modifications
  1. Uuid
    b6d84ed4-a5c4-430f-89a5-97fa424f0563
    Structural modification type
    GENE_EXPRESSION VECTOR
    Molecular fragment
    Uuid
    abff5885-c424-437e-a90c-3bd957b4faab
    Refuuid
    e5b2551d-8833-4f16-844d-a9ae64fd8dd9
    Name
    TEBROCABTAGENE AUTOLEUCEL VECTOR
    UNII
    DM4ANZ9B4N
    Linking ID
    DM4ANZ9B4N
    Ref pname
    TEBROCABTAGENE AUTOLEUCEL VECTOR
    Substance class
    reference
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Data from openFDA, FDA's public API. FDA says not to rely on it to make decisions about medical care and to treat every result as unvalidated; confirm against FDA's own record and the product labeling. Not medical or legal advice.